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Shortened Ca(2+) Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death

RATIONALE: Diastolic spontaneous Ca(2+) waves (DCWs) are recognized as important contributors to triggered arrhythmias. DCWs are thought to arise when [Ca(2+)] in sarcoplasmic reticulum ([Ca(2+)](SR)) reaches a certain threshold level, which might be reduced in cardiac disease as a consequence of se...

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Autors principals: Belevych, Andriy E., Terentyev, Dmitry, Terentyeva, Radmila, Ho, Hsiang-Ting, Gyorke, Inna, Bonilla, Ingrid M., Carnes, Cynthia A., Billman, George E., Györke, Sandor
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068617/
https://ncbi.nlm.nih.gov/pubmed/22223353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.260455
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