The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice

Total body irradiation (TBI) leads to dose- and tissue-specific lethality. In the current study, we demonstrate that a mitochondrion-targeted nitroxide JP4-039 given once 24 hours after 9–10 Gy TBI significantly improves mouse survival, and the recovery of intestinal barrier, differentiation and ste...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Wei, Liang, Leibowitz, Brian J., Epperly, Michael, Bi, Cheng, Li, Allen, Steinman, Justin, Wipf, Peter, Li, Song, Zhang, Lin, Greenberger, Joel, Yu, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794877/
https://ncbi.nlm.nih.gov/pubmed/29391546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20370-9
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