Intraesophageal Administration of GS-Nitroxide (JP4-039) Protects Against Ionizing Irradiation-induced Esophagitis

BACKGROUND/AIM: This study evaluated esophageal radioprotection by the Gramicidin S (GS) derived-nitroxide, JP4-039, a mitochondrial targeting peptide-isostere covalently-linked to 4-amino-Tempo, delivered in a novel swallowed oil-based (F15) formulation. MATERIALS AND METHODS: C57BL/6HNsd female mi...

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Autors principals: EPPERLY, MICHAEL W., GOFF, JULIE P., LI, SONG, GAO, XIANG, WIPF, PETER, DIXON, TRACY, WANG, HONG, FRANICOLA, DARCY, SHEN, HONGMEI, RWIGEMA, JEAN-CLAUDE M., KAGAN, VALERIAN, BERNARD, MARK, GREENBERGER, JOEL S.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521523/
https://ncbi.nlm.nih.gov/pubmed/21164038
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