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Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease

Cyclic AMP promotes cyst growth in polycystic kidney disease (PKD) by stimulating cell proliferation and fluid secretion. Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase an...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Wang, Qian, Cobo-Stark, Patricia, Patel, Vishal, Somlo, Stefan, Han, Pyung-Lim, Igarashi, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794572/
https://ncbi.nlm.nih.gov/pubmed/29042084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.08.005
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