Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease

Cyclic AMP promotes cyst growth in polycystic kidney disease (PKD) by stimulating cell proliferation and fluid secretion. Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase an...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Kidney Int
Hoofdauteurs: Wang, Qian, Cobo-Stark, Patricia, Patel, Vishal, Somlo, Stefan, Han, Pyung-Lim, Igarashi, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794572/
https://ncbi.nlm.nih.gov/pubmed/29042084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.08.005
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items