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Adenylyl Cyclase 6 Deficiency Ameliorates Polycystic Kidney Disease
cAMP is an important mediator of cystogenesis in polycystic kidney disease (PKD). Several adenylyl cyclase (AC) isoforms could mediate cAMP accumulation in PKD, and identification of a specific pathogenic AC isoform is of therapeutic interest. We investigated the role of AC6 in a mouse model of PKD...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Nephrology
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904559/ https://ncbi.nlm.nih.gov/pubmed/24158982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013010077 |
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