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Adenylyl Cyclase 6 Deficiency Ameliorates Polycystic Kidney Disease

cAMP is an important mediator of cystogenesis in polycystic kidney disease (PKD). Several adenylyl cyclase (AC) isoforms could mediate cAMP accumulation in PKD, and identification of a specific pathogenic AC isoform is of therapeutic interest. We investigated the role of AC6 in a mouse model of PKD...

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Main Authors: Rees, Sara, Kittikulsuth, Wararat, Roos, Karl, Strait, Kevin A., Van Hoek, Alfred, Kohan, Donald E.
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904559/
https://ncbi.nlm.nih.gov/pubmed/24158982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013010077
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