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Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1
The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that is a major therapeutic target for the treatment of type 2 diabetes. Activation of this receptor promotes insulin secretion and blood glucose regulation. The GLP-1R can initiate signaling through several intrac...
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| Опубликовано в: : | Biochem Pharmacol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794489/ https://ncbi.nlm.nih.gov/pubmed/28363772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.03.018 |
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