Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

Inhibiting the glutamate/cystine antiporter system x(c)(−), a key antioxidant defense machinery in the CNS, could trigger a novel form of regulated necrotic cell death, ferroptosis. The underlying mechanisms of system x(c)(−)-dependent cell demise were elucidated using primary oligodendrocytes (OLs)...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Novgorodov, Sergei A., Voltin, Joshua R., Gooz, Monika A., Li, Li, Lemasters, John J., Gudz, Tatyana I.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794425/
https://ncbi.nlm.nih.gov/pubmed/29282302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080374
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