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Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
Inhibiting the glutamate/cystine antiporter system x(c)(−), a key antioxidant defense machinery in the CNS, could trigger a novel form of regulated necrotic cell death, ferroptosis. The underlying mechanisms of system x(c)(−)-dependent cell demise were elucidated using primary oligodendrocytes (OLs)...
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| Publicado no: | J Lipid Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794425/ https://ncbi.nlm.nih.gov/pubmed/29282302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080374 |
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