Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis

Inhibiting the glutamate/cystine antiporter system x(c)(−), a key antioxidant defense machinery in the CNS, could trigger a novel form of regulated necrotic cell death, ferroptosis. The underlying mechanisms of system x(c)(−)-dependent cell demise were elucidated using primary oligodendrocytes (OLs)...

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Библиографические подробности
Опубликовано в: :J Lipid Res
Главные авторы: Novgorodov, Sergei A., Voltin, Joshua R., Gooz, Monika A., Li, Li, Lemasters, John J., Gudz, Tatyana I.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794425/
https://ncbi.nlm.nih.gov/pubmed/29282302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080374
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