Identifying specificity groups in the T cell receptor repertoire

T cell receptor (TCR) sequences are very diverse, with many more possible sequence combinations than T cells in any one individual(1–4). Here we define the minimal requirements for TCR antigen specificity, through an analysis of TCR sequences using a panel of peptide and major histocompatibility com...

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Udgivet i:Nature
Main Authors: Glanville, Jacob, Huang, Huang, Nau, Allison, Hatton, Olivia, Wagar, Lisa E., Rubelt, Florian, Ji, Xuhuai, Han, Arnold, Krams, Sheri M., Pettus, Christina, Haas, Nikhil, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Boyd, Scott D., Scriba, Thomas J., Martinez, Olivia M., Davis, Mark M.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794212/
https://ncbi.nlm.nih.gov/pubmed/28636589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22976
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