Src Kinase and Syk Activation Initiate PI3K Signaling by a Chimeric Latent Membrane Protein 1 in Epstein-Barr Virus (EBV)+ B Cell Lymphomas

The B lymphotrophic γ-herpesvirus EBV is associated with a variety of lymphoid- and epithelial-derived malignancies, including B cell lymphomas in immunocompromised and immunosuppressed individuals. The primary oncogene of EBV, latent membrane protein 1 (LMP1), activates the PI3K/Akt pathway to indu...

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Bibliographic Details
Main Authors: Hatton, Olivia, Lambert, Stacie L., Krams, Sheri M., Martinez, Olivia M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411813/
https://ncbi.nlm.nih.gov/pubmed/22880054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042610
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