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Structural investigations on mechanism of lapatinib resistance caused by HER-2 mutants
HER-2 belongs to the human epidermal growth factor receptor (HER) family. Via different signal transduction pathways, HER-2 regulates normal cell proliferation, survival, and differentiation. Recently, it was reported that MCF10A, BT474, and MDA-MB-231 cells bearing the HER2 K753E mutation were resi...
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| Udgivet i: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5794075/ https://ncbi.nlm.nih.gov/pubmed/29389942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190942 |
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