Resolving systematic errors in widely-used enhancer activity assays in human cells

The identification of transcriptional enhancers in the human genome is a prime goal in biology. Enhancers are typically predicted via chromatin marks, yet their function is primarily assessed with plasmid-based reporter assays. Here, we show that two previous observations relating to plasmid-transfe...

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Gepubliceerd in:Nat Methods
Hoofdauteurs: Muerdter, Felix, Boryń, Łukasz M., Woodfin, Ashley R., Neumayr, Christoph, Rath, Martina, Zabidi, Muhammad A., Pagani, Michaela, Haberle, Vanja, Kazmar, Tomáš, Catarino, Rui R., Schernhuber, Katharina, Arnold, Cosmas D., Stark, Alexander
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793997/
https://ncbi.nlm.nih.gov/pubmed/29256496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4534
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