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Cytosolic Proteostasis via Importing of Misfolded Proteins into Mitochondria
Loss of proteostasis underlies aging and neurodegeneration characterized by the accumulation of protein aggregates and mitochondrial dysfunction(1–5). Although many neurodegenerative-disease proteins can be found in mitochondria(4,6), it remains unclear how these disease manifestations may be relate...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5793917/ https://ncbi.nlm.nih.gov/pubmed/28241148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21695 |
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