High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins

Protein aggregation is associated with neurodegeneration and various other pathologies. How specific cellular environments modulate the aggregation of disease proteins is not well understood. Here, we investigated how the endoplasmic reticulum (ER) quality control system handles β‐sheet proteins tha...

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Vydáno v:EMBO J
Hlavní autoři: Vincenz‐Donnelly, Lisa, Holthusen, Hauke, Körner, Roman, Hansen, Erik C, Presto, Jenny, Johansson, Jan, Sawarkar, Ritwick, Hartl, F Ulrich, Hipp, Mark S
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793802/
https://ncbi.nlm.nih.gov/pubmed/29247078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695841
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