CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells

The outer mitochondrial membrane translocator protein (TSPO) binds cholesterol with high affinity and is involved in mediating its delivery into mitochondria, the rate-limiting step in hormone-induced steroidogenesis. Specific ligand binding to TSPO has been shown to initiate steroid formation. Howe...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Fan, Jinjiang, Wang, Kevin, Zirkin, Barry, Papadopoulos, Vassilios
Format: Artigo
Language:Inglês
Published: Endocrine Society 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793793/
https://ncbi.nlm.nih.gov/pubmed/29300865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-03065
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