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Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells

Prostate cancer stem-like cells (PCSCs) are not only enriched in the CD44(+)PSA(−/lo) subpopulation but also employ androgen-independent signaling mechanisms for survival. CD44(+) PCSCs defy androgen deprivation, resist chemo- and radiotherapy and are highly tumorigenic. Human prostate tissue microa...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Mahajan, Nupam P., Coppola, Domenico, Kim, Jongphil, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Kiran
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792546/
https://ncbi.nlm.nih.gov/pubmed/29386546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20172-z
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