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Development of Novel ACK1/TNK2 Inhibitors Using a Fragment-Based Approach
The tyrosine kinase ACK1, a critical signal transducer regulating survival of hormone-refractory cancers, is an important therapeutic target, for which there are no selective inhibitors in clinical trials to date. This work reports the discovery of novel and potent inhibitors for ACK1 tyrosine kinas...
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| Pubblicato in: | J Med Chem |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4605435/ https://ncbi.nlm.nih.gov/pubmed/25699576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501929n |
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