ACK1 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration Resistant Prostate Cancer

Androgen receptor (AR) is critical for the progression of prostate cancer to castration resistant (CRPC) state. AR antagonists are ineffective due to their inability to repress the expression of AR or its splice variant, AR-V7. Here, we report that the tyrosine kinase ACK1 (TNK2) phosphorylates hist...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Mahajan, Kiran, Malla, Pavani, Lawrence, Harshani R., Chen, Zhihua, Sinha, Chandan K., Malik, Rohit, Shukla, Sudhanshu, Kim, Jongphil, Coppola, Domenico, Lawrence, Nicholas J., Mahajan, Nupam P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512571/
https://ncbi.nlm.nih.gov/pubmed/28609657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.05.003
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