Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

Dendritic spine loss is recognized as an early feature of Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Dendritic spine structure is defined by filamentous actin (F-actin) and we observed depolymerization of synaptosomal F-actin accompanied by increased globular...

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Pubblicato in:J Neurosci
Autori principali: Kommaddi, Reddy Peera, Das, Debajyoti, Karunakaran, Smitha, Nanguneri, Siddharth, Bapat, Deepti, Ray, Ajit, Shaw, Eisha, Bennett, David A., Nair, Deepak, Ravindranath, Vijayalakshmi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792472/
https://ncbi.nlm.nih.gov/pubmed/29246925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2127-17.2017
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