Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

Dendritic spine loss is recognized as an early feature of Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Dendritic spine structure is defined by filamentous actin (F-actin) and we observed depolymerization of synaptosomal F-actin accompanied by increased globular...

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Publicado en:J Neurosci
Autores principales: Kommaddi, Reddy Peera, Das, Debajyoti, Karunakaran, Smitha, Nanguneri, Siddharth, Bapat, Deepti, Ray, Ajit, Shaw, Eisha, Bennett, David A., Nair, Deepak, Ravindranath, Vijayalakshmi
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2018
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5792472/
https://ncbi.nlm.nih.gov/pubmed/29246925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2127-17.2017
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