Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease

Aims: Synaptic deficits are known to underlie the cognitive dysfunction seen in Alzheimer's disease (AD). Generation of reactive oxygen species (ROS) by β-amyloid has also been implicated in AD pathogenesis. However, it is unclear whether ROS contributes to synaptic dysfunction seen in AD patho...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Ahmad, Faraz, Singh, Kunal, Das, Debajyoti, Gowaikar, Ruturaj, Shaw, Eisha, Ramachandran, Arathy, Rupanagudi, Khader Valli, Kommaddi, Reddy Peera, Bennett, David A., Ravindranath, Vijayalakshmi
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655421/
https://ncbi.nlm.nih.gov/pubmed/28264587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6860
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