Drug Metabolism in Human Brain: High Levels of Cytochrome P4503A43 in Brain and Metabolism of Anti-Anxiety Drug Alprazolam to Its Active Metabolite

Cytochrome P450 (P450) is a super-family of drug metabolizing enzymes. P450 enzymes have dual function; they can metabolize drugs to pharmacologically inactive metabolites facilitating their excretion or biotransform them to pharmacologically active metabolites which may have longer half-life than t...

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Главные авторы: Agarwal, Varsha, Kommaddi, Reddy P., Valli, Khader, Ryder, Daniel, Hyde, Thomas M., Kleinman, Joel E., Strobel, Henry W., Ravindranath, Vijayalakshmi
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2008
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408964/
https://ncbi.nlm.nih.gov/pubmed/18545703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002337
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