Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

Calpain hyperactivation is implicated in late-stages of neurodegenerative diseases including Alzheimer’s disease (AD). However, calpains are also critical for synaptic function and plasticity, and hence memory formation and learning. Since synaptic deficits appear early in AD pathogenesis prior to a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ahmad, Faraz, Das, Debajyoti, Kommaddi, Reddy Peera, Diwakar, Latha, Gowaikar, Ruturaj, Rupanagudi, Khader Valli, Bennett, David A., Ravindranath, Vijayalakshmi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120938/
https://ncbi.nlm.nih.gov/pubmed/30177812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31073-6
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