Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia

Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker. IGHV mutational status has not been previously examined in canine CLL. We sequenced the IGHV-D-J rearrangements fr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rout, Emily D., Burnett, Robert C., Labadie, Julia D., Yoshimoto, Janna A., Avery, Anne C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791963/
https://ncbi.nlm.nih.gov/pubmed/29385200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191205
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