Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia

Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker. IGHV mutational status has not been previously examined in canine CLL. We sequenced the IGHV-D-J rearrangements fr...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Rout, Emily D., Burnett, Robert C., Labadie, Julia D., Yoshimoto, Janna A., Avery, Anne C.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791963/
https://ncbi.nlm.nih.gov/pubmed/29385200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191205
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