Preferential use of unmutated immunoglobulin heavy variable region genes in Boxer dogs with chronic lymphocytic leukemia

Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status is an important prognostic marker. IGHV mutational status has not been previously examined in canine CLL. We sequenced the IGHV-D-J rearrangements fr...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Rout, Emily D., Burnett, Robert C., Labadie, Julia D., Yoshimoto, Janna A., Avery, Anne C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791963/
https://ncbi.nlm.nih.gov/pubmed/29385200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191205
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