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Pan-cancer analysis of somatic copy number alterations implicates IRS4 and IGF2 in enhancer hijacking

Extensive prior research has focused on somatic copy-number alterations (SCNAs) affecting cancer genes, yet the extent to which recurrent SCNAs exert their influence through rearranging cis-regulatory elements remains unclear. Here, we present a framework for inferring cancer-related gene overexpres...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Genet
Main Authors: Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P., Mardin, Balca R., Chen, Yuanyuan, Stütz, Adrian M., Waszak, Sebastian M., Bosco, Graziella, Halvorsen, Ann Rita, Raeder, Benjamin, Efthymiopoulos, Theocharis, Erkek, Serap, Siegl, Christine, Brenner, Hermann, Brustugun, Odd Terje, Dieter, Sebastian M., Northcott, Paul A., Petersen, Iver, Pfister, Stefan M., Schneider, Martin, Solberg, Steinar K., Thunissen, Erik, Weichert, Wilko, Zichner, Thomas, Thomas, Roman, Peifer, Martin, Helland, Aslaug, Ball, Claudia R., Jechlinger, Martin, Sotillo, Rocio, Glimm, Hanno, Korbel, Jan O.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791882/
https://ncbi.nlm.nih.gov/pubmed/27869826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3722
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