Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells

TP53 deficiency is the most common alteration in cancer; however, this alone is typically insufficient to drive tumorigenesis. To identify genes promoting tumorigenesis in combination with TP53 deficiency, we perform genome-wide CRISPR-Cas9 knockout screens coupled with proliferation and transformat...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Drainas, Alexandros P., Lambuta, Ruxandra A., Ivanova, Irina, Serçin, Özdemirhan, Sarropoulos, Ioannis, Smith, Mike L., Efthymiopoulos, Theocharis, Raeder, Benjamin, Stütz, Adrian M., Waszak, Sebastian M., Mardin, Balca R., Korbel, Jan O.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166082/
https://ncbi.nlm.nih.gov/pubmed/32268084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.03.029
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