Filaggrin Mutations Increase Allergic Airway Disease in Childhood and Adolescence Through Interactions with Eczema and Aeroallergen Sensitization

BACKGROUND: Filaggrin loss-of-function (FLG-LOF) mutations are an established genetic cause of eczema. These mutations have subsequently been reported to increase the risk of aeroallergen sensitization and allergic airway disease. However, it is unclear whether FLG variants require both eczema and a...

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Vydáno v:Clin Exp Allergy
Hlavní autoři: Chan, Adrian, Terry, William, Zhang, Hongmei, Karmaus, Wilfried, Ewart, Susan, Holloway, John W., Roberts, Graham, Kurukulaaratchy, Ramesh, Arshad, Syed Hasan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790610/
https://ncbi.nlm.nih.gov/pubmed/29266469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.13077
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