HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape

Immune-checkpoint inhibitors show encouraging results in cancer treatment, but the clinical benefit is limited exclusively to a subset of patients. We analyzed the density and composition of tumor T-cell infiltration in non-small-cell lung carcinoma (NSCLC) in relation to PD-L1 and HLA class I (HLA-...

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Publicado en:Oncotarget
Autores principales: Perea, Francisco, Sánchez-Palencia, Abel, Gómez-Morales, Mercedes, Bernal, Mónica, Concha, Ángel, García, Míguela Méndez, González-Ramírez, Amanda Rocío, Kerick, Martin, Martin, Javier, Garrido, Federico, Ruiz-Cabello, Francisco, Aptsiauri, Natalia
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790526/
https://ncbi.nlm.nih.gov/pubmed/29423109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23469
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