A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment

Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimized immunocytokines that, when injected in mice, only reveal their activity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncoimmunology
Prif Awduron: Cauwels, Anje, Van Lint, Sandra, Garcin, Geneviève, Bultinck, Jennyfer, Paul, Franciane, Gerlo, Sarah, Van der Heyden, José, Bordat, Yann, Catteeuw, Dominiek, De Cauwer, Lode, Rogge, Elke, Verhee, Annick, Uzé, Gilles, Tavernier, Jan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2017
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790344/
https://ncbi.nlm.nih.gov/pubmed/29399401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1398876
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