A safe and highly efficient tumor-targeted type I interferon immunotherapy depends on the tumor microenvironment

Despite approval for the treatment of various malignancies, clinical application of cytokines such as type I interferon (IFN) is severely impeded by their systemic toxicity. AcTakines (Activity-on-Target cytokines) are optimized immunocytokines that, when injected in mice, only reveal their activity...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Cauwels, Anje, Van Lint, Sandra, Garcin, Geneviève, Bultinck, Jennyfer, Paul, Franciane, Gerlo, Sarah, Van der Heyden, José, Bordat, Yann, Catteeuw, Dominiek, De Cauwer, Lode, Rogge, Elke, Verhee, Annick, Uzé, Gilles, Tavernier, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790344/
https://ncbi.nlm.nih.gov/pubmed/29399401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1398876
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