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Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes

Chromosomal translocations drive the development of many hematological and some solid cancers. Several factors have been identified to explain the non-random occurrence of translocation breakpoints in the genome. These include chromatin density, gene density and CCCTC-binding factor (CTCF)/cohesin b...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Lin, Cheng-Yu, Shukla, Ankit, Grady, John P., Fink, J. Lynn, Dray, Eloise, Duijf, Pascal H.G.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789363/
https://ncbi.nlm.nih.gov/pubmed/29316705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10010013
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