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Cancer cells preferentially lose small chromosomes
Genetic and genomic aberrations are the primary cause of cancer. Chromosome missegregation leads to aneuploidy and provides cancer cells with a mechanism to lose tumor suppressor loci and gain extra copies of oncogenes. Using cytogenetic and array-based comparative genomic hybridization data, we ana...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587043/ https://ncbi.nlm.nih.gov/pubmed/23124507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27924 |
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