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Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma

BACKGROUND: Gliosarcoma is a rare variant of glioblastoma (GBM) that exhibits frequent mutations in TP53 and can develop in a secondary fashion after chemoradiation of a primary GBM. Whether temozolomide (TMZ)-induced mutagenesis of the TP53 DNA-binding domain (DBD) can drive the pathogenesis of gli...

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發表在:Oncotarget
Main Authors: Pain, Margaret, Wang, Huaien, Lee, Eunjee, Strahl, Maya, Hamou, Wissam, Sebra, Robert, Zhu, Jun, Yong, Raymund L.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788663/
https://ncbi.nlm.nih.gov/pubmed/29416795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23517
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