TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, which is refractory to all currently available treatments and bears dismal prognosis. About 70% of all PDAC cases harbor mutations in the TP53 tumor suppressor gene. Many of those are missense mutations, resulting in abundant product...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Maddalena, Martino, Mallel, Giuseppe, Nataraj, Nishanth Belugali, Shreberk-Shaked, Michal, Hassin, Ori, Mukherjee, Saptaparna, Arandkar, Sharathchandra, Rotkopf, Ron, Kapsack, Abby, Lambiase, Giuseppina, Pellegrino, Bianca, Ben-Isaac, Eyal, Golani, Ofra, Addadi, Yoseph, Hajaj, Emma, Eilam, Raya, Straussman, Ravid, Yarden, Yosef, Lotem, Michal, Oren, Moshe
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201917/
https://ncbi.nlm.nih.gov/pubmed/34088837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025631118
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