Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity

MeCP2 binds to methylated DNA in a chromatin context and has an important role in cancer and brain development and function. Histone deacetylase (HDAC) inhibitors are currently being used to palliate many cancer and neurological disorders. Yet, the molecular mechanisms involved are not well known fo...

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Veröffentlicht in:Epigenetics
Hauptverfasser: Good, Katrina V., Martínez de Paz, Alexia, Tyagi, Monica, Cheema, Manjinder S., Thambirajah, Anita A., Gretzinger, Taylor L., Stefanelli, Gilda, Chow, Robert L., Krupke, Oliver, Hendzel, Michael, Missiaen, Kristal, Underhill, Alan, Landsberger, Nicoletta, Ausió, Juan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788420/
https://ncbi.nlm.nih.gov/pubmed/29099289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2017.1380760
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