Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association

MeCP2 is a transcriptional regulator whose functional alterations are responsible for several autism spectrum and mental disorders. Post-translational modifications (PTMs), and particularly differential phosphorylation, modulate MeCP2 function in response to diverse stimuli. Understanding the detail...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Stefanelli, Gilda, Gandaglia, Anna, Costa, Mario, Cheema, Manjinder S., Di Marino, Daniele, Barbiero, Isabella, Kilstrup-Nielsen, Charlotte, Ausió, Juan, Landsberger, Nicoletta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915018/
https://ncbi.nlm.nih.gov/pubmed/27323888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28295
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