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The conformational epitope for a new Aβ42 protofibril-selective antibody partially overlaps with the peptide N-terminal region
Aggregation and accumulation of amyloid-β peptide (Aβ) is a key component of Alzheimer's disease (AD). While monomeric Aβ appears to be benign, oligomers adopt a biologically detrimental structure. These soluble structures can be detected in AD brain tissue by antibodies that demonstrate select...
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| Udgivet i: | J Neurochem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788191/ https://ncbi.nlm.nih.gov/pubmed/28881033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14211 |
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