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Aβ40 has a subtle effect on Aβ42 protofibril formation, but to a lesser degree than Aβ42 concentration, in Aβ42/Aβ40 mixtures

Recent findings suggest that the senile plaques in Alzheimer’s disease may contain soluble amyloid-β peptide (Aβ) fibril precursors along with insoluble fibrils.. These soluble Aβ species, including oligomers and protofibrils, have been well-studied in vitro and are formed via non-covalent self-asse...

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Библиографические подробности
Опубликовано в: :Arch Biochem Biophys
Главные авторы: Terrill-Usery, Shana E., Colvin, Benjamin A., Davenport, Richard E., Nichols, Michael R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841699/
https://ncbi.nlm.nih.gov/pubmed/27013205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.03.017
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