Mutual Regulation of Tumour Vessel Normalization and Immunostimulatory Reprogramming

Blockade of angiogenesis can retard tumour growth, but may also paradoxically increase metastasis(1,2). Vessel normalization (VN) may resolve this paradox(3). VN involves increased pericyte coverage, improved tumour vessel perfusion, reduced vascular permeability, and consequently mitigated hypoxia(...

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Vydáno v:Nature
Hlavní autoři: Tian, Lin, Goldstein, Amit, Wang, Hai, Lo, Hin Ching, Kim, Ik Sun, Welte, Thomas, Sheng, Kuanwei, Dobrolecki, Lacey E., Zhang, Xiaomei, Putluri, Nagireddy, Phung, Thuy L., Mani, Sendurai A., Stossi, Fabio, Sreekumar, Arun, Mancini, Michael A., Decker, William K., Zong, Chenghang, Lewis, Michael T., Zhang, Xiang H.-F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788037/
https://ncbi.nlm.nih.gov/pubmed/28371798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21724
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