Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

The majority of breast cancer models for drug discovery are based on orthotopic or subcutaneous tumours. Therapeutic responses of metastases, especially microscopic metastases, are likely to differ from these tumours due to distinct cancer-microenvironment crosstalk in distant organs. Here, to recap...

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I publikationen:Nat Commun
Huvudupphovsmän: Wang, Hai, Tian, Lin, Goldstein, Amit, Liu, Jun, Lo, Hin-Ching, Sheng, Kuanwei, Welte, Thomas, Wong, Stephen T.C., Gugala, Zbigniew, Stossi, Fabio, Zong, Chenghang, Li, Zonghai, Mancini, Michael A., Zhang, Xiang H.-F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413944/
https://ncbi.nlm.nih.gov/pubmed/28429794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15045
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