The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability

The fate of disseminated tumor cells is largely determined by microenvironment (ME) niche. The osteogenic niche promotes cancer cell proliferation and bone metastasis progression. We investigated the underlying mechanisms using pre-clinical models and analyses of clinical data. We discovered that th...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Wang, Hai, Tian, Lin, Liu, Jun, Goldstein, Amit, Bado, Igor, Zhang, Weijie, Arenkiel, Benjamin R., Li, Zonghai, Yang, Meng, Du, Shiyu, Zhao, Hong, Rowley, David R., Wong, Stephen T. C., Gugala, Zbigniew, Zhang, Xiang H.-F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239211/
https://ncbi.nlm.nih.gov/pubmed/30423299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.002
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