The osteogenic niche is a calcium reservoir of bone micrometastases and confers unexpected therapeutic vulnerability

The fate of disseminated tumor cells is largely determined by microenvironment (ME) niche. The osteogenic niche promotes cancer cell proliferation and bone metastasis progression. We investigated the underlying mechanisms using pre-clinical models and analyses of clinical data. We discovered that th...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Wang, Hai, Tian, Lin, Liu, Jun, Goldstein, Amit, Bado, Igor, Zhang, Weijie, Arenkiel, Benjamin R., Li, Zonghai, Yang, Meng, Du, Shiyu, Zhao, Hong, Rowley, David R., Wong, Stephen T. C., Gugala, Zbigniew, Zhang, Xiang H.-F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239211/
https://ncbi.nlm.nih.gov/pubmed/30423299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.002
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