Mutual Regulation of Tumour Vessel Normalization and Immunostimulatory Reprogramming

Blockade of angiogenesis can retard tumour growth, but may also paradoxically increase metastasis(1,2). Vessel normalization (VN) may resolve this paradox(3). VN involves increased pericyte coverage, improved tumour vessel perfusion, reduced vascular permeability, and consequently mitigated hypoxia(...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Tian, Lin, Goldstein, Amit, Wang, Hai, Lo, Hin Ching, Kim, Ik Sun, Welte, Thomas, Sheng, Kuanwei, Dobrolecki, Lacey E., Zhang, Xiaomei, Putluri, Nagireddy, Phung, Thuy L., Mani, Sendurai A., Stossi, Fabio, Sreekumar, Arun, Mancini, Michael A., Decker, William K., Zong, Chenghang, Lewis, Michael T., Zhang, Xiang H.-F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788037/
https://ncbi.nlm.nih.gov/pubmed/28371798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21724
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