Modeling signaling‐dependent pluripotency with Boolean logic to predict cell fate transitions

Pluripotent stem cells (PSCs) exist in multiple stable states, each with specific cellular properties and molecular signatures. The mechanisms that maintain pluripotency, or that cause its destabilization to initiate development, are complex and incompletely understood. We have developed a model to...

Full description

Saved in:
Bibliographic Details
Published in:Mol Syst Biol
Main Authors: Yachie‐Kinoshita, Ayako, Onishi, Kento, Ostblom, Joel, Langley, Matthew A, Posfai, Eszter, Rossant, Janet, Zandstra, Peter W
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787708/
https://ncbi.nlm.nih.gov/pubmed/29378814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20177952
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items