PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation

Alpha-synuclein (α-Syn) and phosphatase and tensin homolog deleted on chromosome ten (PTEN)-induced putative kinase (PINK) 1 are proteins found in Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). PINK1 overexpression suppresses α-Syn-induced phenotypes and increases lifesp...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yang, Weiwei, Wang, Xue, Liu, Jia, Duan, Chunli, Gao, Ge, Lu, Lingling, Yu, Shun, Yang, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper: Gerotarget (Focus on Aging)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787472/
https://ncbi.nlm.nih.gov/pubmed/29416594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21554
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