Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

The pathology of Parkinson’s disease (PD) is characterized by intracellular neurofibrillary tangles of phosphorylated α-synuclein (α-syn). Protein phosphatase 2A (PP2A) is responsible for α-syn dephosphorylation. Previous work has demonstrated that α-syn can regulate PP2A activity. However, the mech...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Aging Neurosci
Auteurs principaux: Tian, Hao, Lu, Yongquan, Liu, Jia, Liu, Weijin, Lu, Lingling, Duan, Chunli, Gao, Ge, Yang, Hui
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008559/
https://ncbi.nlm.nih.gov/pubmed/29950985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00173
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