An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane insertion facilitates water reabsorption from prim...

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Vydáno v:PLoS One
Hlavní autoři: Schrade, Katharina, Tröger, Jessica, Eldahshan, Adeeb, Zühlke, Kerstin, Abdul Azeez, Kamal R., Elkins, Jonathan M., Neuenschwander, Martin, Oder, Andreas, Elkewedi, Mohamed, Jaksch, Sarah, Andrae, Karsten, Li, Jinliang, Fernandes, Joao, Müller, Paul Markus, Grunwald, Stephan, Marino, Stephen F., Vukićević, Tanja, Eichhorst, Jenny, Wiesner, Burkhard, Weber, Marcus, Kapiloff, Michael, Rocks, Oliver, Daumke, Oliver, Wieland, Thomas, Knapp, Stefan, von Kries, Jens Peter, Klussmann, Enno
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786306/
https://ncbi.nlm.nih.gov/pubmed/29373579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191423
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