Circadian alterations during early stages of Alzheimer’s disease are associated with aberrant cycles of DNA methylation in BMAL1

INTRODUCTION: Circadian alterations are prevalent in Alzheimer’s disease (AD) and may contribute to cognitive impairment, behavioral symptoms and neurodegeneration. Epigenetic mechanisms regulate the circadian clock, and changes in DNA methylation have been reported in AD brains, but the pathways th...

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Bibliografski detalji
Izdano u:Alzheimers Dement
Glavni autori: Cronin, Peter, McCarthy, Michael J., Lim, Andrew S.P., Salmon, David P., Galasko, Douglas, Masliah, Eliezer, De Jager, Philip L., Bennett, David A., Desplats, Paula
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785929/
https://ncbi.nlm.nih.gov/pubmed/27883893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.10.003
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