Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy

Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder characterized by mutations in either the TSC1 or TSC2 genes whose products form a critical inhibitor of the mechanistic target of rapamycin (mTOR). Loss of TSC1/2 gene function renders an mTOR-overactivated state. Clinically, TSC mani...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Lipton, Jonathan O., Boyle, Lara M., Yuan, Elizabeth D., Hochstrasser, Kevin J., Chifamba, Fortunate F., Nathan, Ashwin, Tsai, Peter T., Davis, Fred, Sahin, Mustafa
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603761/
https://ncbi.nlm.nih.gov/pubmed/28746872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.008
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