HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis

HIF-1α, one of the most extensively studied oncogenes, is activated by a variety of microenvironmental factors. The resulting biological effects are thought to depend on its transcriptional activity. The RNAse enzyme Dicer is frequently downregulated in human cancers, which has been functionally lin...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Lai, Hui-Huang, Li, Jie-Ning, Wang, Ming-Yang, Huang, Hsin-Yi, Croce, Carlo M., Sun, Hui-Lung, Lyu, Yu-Jhen, Kang, Jui-Wen, Chiu, Ching-Feng, Hung, Mien-Chie, Suzuki, Hiroshi I., Chen, Pai-Sheng
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2017
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785260/
https://ncbi.nlm.nih.gov/pubmed/29251629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89212
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